Molecular Playground/DnaK: Difference between revisions

DnaK is a 638 residue protein of approximately 70 kDa. The protein can be thought to be made up of two domains, the N-terminal nucleotide-binding domain (<scene name='60/609794/Nbd/4'>NBD</scene>) (residues 1-388), the C-terminal substrate-binding domain (<scene name='60/609794/Sbd/2'>SBD</scene>) (residues 393-638), which are divided by the <scene name='60/609794/Linker/1'>interdomain linker</scene> (residues 389-392, shown in purple between the NBD and SBD).  The NBD is further divided into four subdomains: <scene name='60/609794/Subdomain_ia/2'>IA</scene> (residues 1-37, 112-184, 363-383, shown in red), <scene name='60/609794/Subdomain_ib/2'>IB</scene> (residues 38-111, shown in green), <scene name='60/609794/Subdomain_iia/2'>IIA</scene> (residues 185-227, 310-362, shown in gold), and <scene name='60/609794/Subdomain_iib/2'>IIB</scene> (residues 228-309, shown in purple). The SBD of DnaK consists of a <scene name='60/609794/Beta_basket/1'>beta-basket</scene> (residues 393-507), an <scene name='60/609794/Helical_lid/1'>alpha-helical lid</scene> (residues 508-605), and a disordered C-terminal tail (not shown due to lack of available crystal structure).[http://www.ncbi.nlm.nih.gov/pubmed/22576356]