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-[[Image:3fbn.png|left|200px]]
+==Structure of the Mediator submodule Med7N/31==
+<StructureSection load='3fbn' size='340' side='right' caption='[[3fbn]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3fbn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FBN FirstGlance]. <br>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fbi|3fbi]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MED7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), MED31, SOH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fbn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fbn RCSB], [http://www.ebi.ac.uk/pdbsum/3fbn PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Mediator is a modular multiprotein complex required for regulated transcription by RNA polymerase (Pol) II. Here, we show that the middle module of the Mediator core contains a submodule of unique structure and function that comprises the N-terminal part of subunit Med7 (Med7N) and the highly conserved subunit Med31 (Soh1). The Med7N/31 submodule shows a conserved novel fold, with two proline-rich stretches in Med7N wrapping around the right-handed four-helix bundle of Med31. In vitro, Med7N/31 is required for activated transcription and can act in trans when added exogenously. In vivo, Med7N/31 has a predominantly positive function on the expression of a specific subset of genes, including genes involved in methionine metabolism and iron transport. Comparative phenotyping and transcriptome profiling identify specific and overlapping functions of different Mediator submodules.
-{{STRUCTURE_3fbn|  PDB=3fbn  |  SCENE=  }}
+Identification, structure, and functional requirement of the Mediator submodule Med7N/31.,Koschubs T, Seizl M, Lariviere L, Kurth F, Baumli S, Martin DE, Cramer P EMBO J. 2009 Jan 7;28(1):69-80. Epub 2008 Dec 4. PMID:19057509<ref>PMID:19057509</ref>
-===Structure of the Mediator submodule Med7N/31===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_19057509}}
-==About this Structure==
-[[3fbn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBN OCA].
 ==See Also==
 *[[Mediator|Mediator]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:019057509</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Baumli, S.]]
+[[Category: Baumli, S]]
-[[Category: Cramer, P.]]
+[[Category: Cramer, P]]
-[[Category: Koschubs, T.]]
+[[Category: Koschubs, T]]
-[[Category: Kurth, F.]]
+[[Category: Kurth, F]]
-[[Category: Lariviere, L.]]
+[[Category: Lariviere, L]]
-[[Category: Martin, D E.]]
+[[Category: Martin, D E]]
-[[Category: Seizl, M.]]
+[[Category: Seizl, M]]
 [[Category: Activator]]
 [[Category: Nucleus]]