4wo4: Difference between revisions

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-'''Unreleased structure'''
+==The molecular bases of Delta/Alpha beta T cell-mediated antigen recognition.==
+<StructureSection load='4wo4' size='340' side='right' caption='[[4wo4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-The entry 4wo4 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4wo4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WO4 FirstGlance]. <br>
-Authors: Pellicci, D.G., Uldrich, A.P., Le Nours, J., Ross, F., Chabrol, E., Eckle, S.B.G., de Boer, R., Lim, R.T., McPherson, K., Besra, G., Howell, A.R., Moretta, L., McCluskey, J., Heemskerk, M.H.M., Gras, S., Rossjohn, J., Godfrey, D.I.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=JLS:(15Z)-N-[(2S,3S,4R)-1-(ALPHA-D-GALACTOPYRANOSYLOXY)-3,4-DIHYDROXYOCTADECAN-2-YL]TETRACOS-15-ENAMIDE'>JLS</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wnq|4wnq]]</td></tr>
-Description:
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wo4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wo4 RCSB], [http://www.ebi.ac.uk/pdbsum/4wo4 PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/CD1D_HUMAN CD1D_HUMAN]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:17475845</ref>  [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Besra, G]]
+[[Category: Boer, R de]]
+[[Category: Chabrol, E]]
+[[Category: Eckle, S B.G]]
+[[Category: Godfrey, D I]]
+[[Category: Gras, S]]
+[[Category: Heemskerk, M H.M]]
+[[Category: Howell, A R]]
+[[Category: Lim, R T]]
+[[Category: McCluskey, J]]
+[[Category: McPherson, K]]
+[[Category: Moretta, L]]
+[[Category: Nours, J Le]]
+[[Category: Pellicci, D G]]
+[[Category: Ross, F]]
+[[Category: Rossjohn, J]]
+[[Category: Uldrich, A P]]
+[[Category: Immune system]]
+[[Category: Immunity]]