EPSP synthase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Ann Taylor, Michal Harel, Alexander Berchansky, Joel L. Sussman

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 The enzyme has <scene name='57/570585/Two_domains/1'>two domains</scene>, with the active site found in the interdomain cleft.  There is a substantial structural change upon substrate binding, resulting in a <scene name='57/570585/Closed_formation/1'>closed formation</scene>.  Glyphosate (also known as Roundup) occupies the binding site of the second substrate, phosphoenol pyruvate.
+</StructureSection>
 ===3D structures of EPSP synthase ===
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[1eps]] – EcEPSP – ''Escherichia coli''<br />
+*5-enolpyruvylshikimate 3-phosphate (EPSP) synthase
-[[1p88]], [[1p89]] - EcEPSP N terminal - NMR<br />
-[[1rf5]] - SpEPSP – ''Streptococcus pneumoniae''<br />
-[[2bjb]], [[2o15]] – MtEPSP – ''Mycobacterium tuberculosis''<br />
-[[2gg4]] – AgEPSP – ''Agrobacterium''<br />
-[[3roi]], [[3tr1]], [[4gfp]] – CbEPSP – ''Coxiella burnetii''<br />
-[[3ti2]] - VcEPSP N terminal – ''Vibrio cholerae''<br />
-===EPSP synthase binary complex===
+**[[1eps]] – EcEPSP – ''Escherichia coli''<br />
+**[[1p88]], [[1p89]] - EcEPSP N terminal - NMR<br />
+**[[1rf5]] - SpEPSP – ''Streptococcus pneumoniae''<br />
+**[[2bjb]], [[2o15]] – MtEPSP – ''Mycobacterium tuberculosis''<br />
+**[[2gg4]] – AgEPSP – ''Agrobacterium''<br />
+**[[3roi]], [[3tr1]], [[4gfp]] – CbEPSP – ''Coxiella burnetii''<br />
+**[[3ti2]] - VcEPSP N terminal – ''Vibrio cholerae''<br />
-[[1g6t]] - EcEPSP + S3P <br />
+*EPSP synthase binary complex
-[[1mi4]], [[2qfq]], [[2qfs]], [[3fjx]], [[3fk0]] - EcEPSP (mutant) + S3P <br />
-[[1q36]] - EcEPSP (mutant) + S3P derivative<br />
-[[1x8r]], [[1x8t]] - EcEPSP + intermediate <br />
-[[2aa9]] – EcEPSP + shikimate<br />
-[[2pq9]] - EcEPSP + intermediate <br />
-[[1rf4]] - SpEPSP + intermediate <br />
-[[2o0b]], [[2o0d]] - MtEPSP + S3P <br />
-[[2gg6]] - AgEPSP + S3P <br />
-[[2pqb]], [[2pqc]], [[2pqd]] - AgEPSP + intermediate <br />
-[[2o0x]] - MtEPSP + intermediate <br />
-[[2o0z]] - MtEPSP + EPS <br />
-[[4egr]] - CbEPSP + phosphoenolpyruvate<br />
-===EPSP synthase ternary complex===
+**[[1g6t]] - EcEPSP + S3P <br />
+**[[1mi4]], [[2qfq]], [[2qfs]], [[3fjx]], [[3fk0]] - EcEPSP (mutant) + S3P <br />
+**[[1q36]] - EcEPSP (mutant) + S3P derivative<br />
+**[[1x8r]], [[1x8t]] - EcEPSP + intermediate <br />
+**[[2aa9]] – EcEPSP + shikimate<br />
+**[[2pq9]] - EcEPSP + intermediate <br />
+**[[1rf4]] - SpEPSP + intermediate <br />
+**[[2o0b]], [[2o0d]] - MtEPSP + S3P <br />
+**[[2gg6]] - AgEPSP + S3P <br />
+**[[2pqb]], [[2pqc]], [[2pqd]] - AgEPSP + intermediate <br />
+**[[2o0x]] - MtEPSP + intermediate <br />
+**[[2o0z]] - MtEPSP + EPS <br />
+**[[4egr]] - CbEPSP + phosphoenolpyruvate<br />
-[[1g6p]] - EcEPSP + S3P + glyphosate<br />
+*EPSP synthase ternary complex
-[[2qft]], [[2qfu]], [[3fjz]], [[3fk1]] - EcEPSP (mutant) + S3P + glyphosate<br />
-[[2aay]] - EcEPSP + shikimate + glyphosate<br />
-[[1rf6]] - SpEPSP + S3P + glyphosate<br />
-[[2gga]] - AgEPSP + S3P + glyphosate<br />
-[[4ggd]] - AgEPSP (mutant) + S3P + glyphosate<br />
-[[2o0e]] - MtEPSP + S3P + phosphoenolpyruvate<br />
-[[3nvs]] - VcEPSP + S3P + glyphosate <br />
-[[3slh]] - CbEPSP + S3P + glyphosate<br />
+**[[1g6p]] - EcEPSP + S3P + glyphosate<br />
+**[[2qft]], [[2qfu]], [[3fjz]], [[3fk1]] - EcEPSP (mutant) + S3P + glyphosate<br />
+**[[2aay]] - EcEPSP + shikimate + glyphosate<br />
+**[[1rf6]] - SpEPSP + S3P + glyphosate<br />
+**[[2gga]] - AgEPSP + S3P + glyphosate<br />
+**[[4ggd]] - AgEPSP (mutant) + S3P + glyphosate<br />
+**[[2o0e]] - MtEPSP + S3P + phosphoenolpyruvate<br />
+**[[3nvs]] - VcEPSP + S3P + glyphosate <br />
+**[[3slh]] - CbEPSP + S3P + glyphosate<br />
+}}
-</StructureSection>
 [[Category:Topic Page]]