Epidermal Growth Factor Receptor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, David Canner, Michal Harel, Joel L. Sussman, Jaime Prilusky

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 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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-=== EGFR extracellular domain ===
+* EGFR extracellular domain
-[[3ltf]] – DmEGFR extracellular domain+spitz protein – ''Drosophila melanogaster''<br />
+**[[3ltf]] – DmEGFR extracellular domain+spitz protein – ''Drosophila melanogaster''<br />
-[[3i2t]] - DmEGFR extracellular domain<br />
+**[[3i2t]] - DmEGFR extracellular domain<br />
-[[3n85]] – hERBB2 extracellular domain+FAB37 light and heavy chains – human<br />
+**[[3n85]] – hERBB2 extracellular domain+FAB37 light and heavy chains – human<br />
-[[1yy9]], [[4kro]], [[4krp]] – hERBB1 extracellular domain+antibody<br />
+**[[1yy9]], [[4kro]], [[4krp]] – hERBB1 extracellular domain+antibody<br />
-[[1m6b]] – hERBB3 extracellular domain<br />
+**[[1m6b]] – hERBB3 extracellular domain<br />
-[[1mox]] - hEGFR extracellular domain+TGF alpha<br />
+**[[1mox]] - hEGFR extracellular domain+TGF alpha<br />
-[[1ivo]], [[1nql]], [[3njp]]  - hEGFR extracellular domain+hEGF<br />
+**[[1ivo]], [[1nql]], [[3njp]]  - hEGFR extracellular domain+hEGF<br />
-[[3qwq]] – hEGFR extracellular domain + adnectin<br />
+**[[3qwq]] – hEGFR extracellular domain + adnectin<br />
-[[3ltg]] - EGFR extracellular domain+ Spitz (mutant) – ''Drosophila melanogaster''<br />
+**[[3ltg]] - EGFR extracellular domain+ Spitz (mutant) – ''Drosophila melanogaster''<br />
-[[4krl]], [[4krm]] – EGFR + nanobody – llama<br />
+**[[4krl]], [[4krm]] – EGFR + nanobody – llama<br />
-=== EGFR transmembrane domain ===
+* EGFR transmembrane domain
-[[2ks1]] – hERBB1+hERBB2 transmembrane domains<br />
+**[[2ks1]] – hERBB1+hERBB2 transmembrane domains<br />
-=== EGFR kinase domain ===
+* EGFR kinase domain
-[[3gt8]] – hEGFR kinase domain+peptide+AMPPNP<br />
+**[[3gt8]] – hEGFR kinase domain+peptide+AMPPNP<br />
-[[2gs2]] – hERBB1 kinase domain<br />
+**[[2gs2]] – hERBB1 kinase domain<br />
-[[2gs6]] - hERBB1 kinase domain+peptide<br />
+**[[2gs6]] - hERBB1 kinase domain+peptide<br />
-[[2gs7]] - hERBB1 kinase domain+AMPPNP<br />
+**[[2gs7]] - hERBB1 kinase domain+AMPPNP<br />
-[[2eb2]], [[2jit]], [[1m14]], [[4i1z]], [[4i20]], [[3ug1]] – hERBB1 kinase domain (mutant)<br />
+**[[2eb2]], [[2jit]], [[1m14]], [[4i1z]], [[4i20]], [[3ug1]] – hERBB1 kinase domain (mutant)<br />
-[[2jiu]], [[2jiv]], [[2ito]], [[2itp]], [[2itq]], [[2itt]], [[2itu]], [[2itw]], [[2itz]], [[2j6m]], [[2j5e]], [[2j5f]], [[1m17]], [[3w2o]], [[3w2p]], [[3w2q]], [[3w2r]] [[3w2s]],[[4ll0]], [[4lqm]] - hERBB1 kinase domain (mutant)+inhibitor<br />
+**[[2jiu]], [[2jiv]], [[2ito]], [[2itp]], [[2itq]], [[2itt]], [[2itu]], [[2itw]], [[2itz]], [[2j6m]], [[2j5e]], [[2j5f]], [[1m17]], [[3w2o]], [[3w2p]], [[3w2q]], [[3w2r]] [[3w2s]],[[4ll0]], [[4lqm]] - hERBB1 kinase domain (mutant)+inhibitor<br />
-[[3ug2]], [[2ity]], [[4g5p]], [[4hjo]], [[4i22]], [[4i24]] - hERBB1 kinase domain (mutant) + cancer drug<br />
+**[[3ug2]], [[2ity]], [[4g5p]], [[4hjo]], [[4i22]], [[4i24]] - hERBB1 kinase domain (mutant) + cancer drug<br />
-[[4g5j]], [[4i23]] - hERBB1 kinase domain + cancer drug<br />
+**[[4g5j]], [[4i23]] - hERBB1 kinase domain + cancer drug<br />
-[[2rf9]], [[2rfd]], [[2rfe]], [[1xkk]], [[3lzb]], [[3poz]], [[3w32]], [[3w33]], [[3w2s]], [[4jq7]], [[4jq8]], [[4jr3]], [[4jrv]], [[4li5]], [[4lrm]] - hERBB1 kinase domain+inhibitor<br />
+**[[2rf9]], [[2rfd]], [[2rfe]], [[1xkk]], [[3lzb]], [[3poz]], [[3w32]], [[3w33]], [[3w2s]], [[4jq7]], [[4jq8]], [[4jr3]], [[4jrv]], [[4li5]], [[4lrm]] - hERBB1 kinase domain+inhibitor<br />
-[[2eb3]], [[2itn]], [[2itv]], [[2itx]], [[3vjn]] - hERBB1 kinase domain (mutant)+AMPPNP<br />
+**[[2eb3]], [[2itn]], [[2itv]], [[2itx]], [[3vjn]] - hERBB1 kinase domain (mutant)+AMPPNP<br />
-[[3vjo]] - hERBB1 kinase domain (mutant)+AMPPNP<br />
+**[[3vjo]] - hERBB1 kinase domain (mutant)+AMPPNP<br />
-[[3b2u]] - hERBB1 kinase domain+IMC-11F8 FAB fragment<br />
+**[[3b2u]] - hERBB1 kinase domain+IMC-11F8 FAB fragment<br />
-[[3p0y]] - hERBB1 kinase domain+ FAB<br />
+**[[3p0y]] - hERBB1 kinase domain+ FAB<br />
-[[4i21]] - hERBB1 kinase domain + ERBB receptor feedback inhibitor 1<br />
+**[[4i21]] - hERBB1 kinase domain + ERBB receptor feedback inhibitor 1<br />
-[[3kex]] – hERBB3 kinase domain<br />
+**[[3kex]] – hERBB3 kinase domain<br />
-=== EGFR juxtamembrane domain ===
+* EGFR juxtamembrane domain
-[[3gop]] – hERBB1 kinase and juxtamembrane domains<br />
+**[[3gop]] – hERBB1 kinase and juxtamembrane domains<br />
-[[1z9i]] - hERBB1 juxtamembrane domain<br />
+**[[1z9i]] - hERBB1 juxtamembrane domain<br />
-[[2m20]] – hERBB1 transmembrane and juxtamembrane domains (mutant) - NMR<br />
+**[[2m20]] – hERBB1 transmembrane and juxtamembrane domains (mutant) - NMR<br />
-=== EGFR fragments ===
+* EGFR fragments
-[[3i7z]] – hEGFR fragment+hTyrosine phosphatase<br />
-[[3g5v]], [[3g5y]], [[3g5z]], [[3g5x]] – EGFR fragment+antibody – mouse<br />
-[[3ika]] – hERBB1 (mutant)+inhibitor<br />
-[[2rgp]] – hERBB1+hydrazone<br />
-[[3bel]] – hERBB1+oxime<br />
-[[3c09]] – hERBB1 domain III+antibody<br />
-[[2b2u]], [[3b2v]] – hERBB1 fragment+antibody<br />
-[[3buo]] – EGFR 13-mer+hCBL N-terminal<br />
+**[[3i7z]] – hEGFR fragment+hTyrosine phosphatase<br />
+**[[3g5v]], [[3g5y]], [[3g5z]], [[3g5x]] – EGFR fragment+antibody – mouse<br />
+**[[3ika]] – hERBB1 (mutant)+inhibitor<br />
+**[[2rgp]] – hERBB1+hydrazone<br />
+**[[3bel]] – hERBB1+oxime<br />
+**[[3c09]] – hERBB1 domain III+antibody<br />
+**[[2b2u]], [[3b2v]] – hERBB1 fragment+antibody<br />
+**[[3buo]] – EGFR 13-mer+hCBL N-terminal<br />
+}}
 ==Additional Resources==
 For additional information, see: [[Cancer]]