CD3: Difference between revisions
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'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants. | '''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants. | ||
</StructureSection> | |||
==3D structures of CD3== | ==3D structures of CD3== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*CD3 ε chain | |||
[[1a81]] – hCD3 ITAM + Syk kinase – human <BR /> | **[[1a81]] – hCD3 ITAM + Syk kinase – human <BR /> | ||
[[2jxb]] – hCD3 domain SH3-1<br /> | **[[2jxb]] – hCD3 domain SH3-1<br /> | ||
[[2k4f]] – mCD3 ITAM – mouse - NMR <BR /> | **[[2k4f]] – mCD3 ITAM – mouse - NMR <BR /> | ||
[[3r08]] – mCD3 extracellular domain + antibody<BR /> | **[[3r08]] – mCD3 extracellular domain + antibody<BR /> | ||
*CD3 εγ dimer | |||
[[1jbj]] – hCD3 extracellular domain - NMR<BR /> | **[[1jbj]] – hCD3 extracellular domain - NMR<BR /> | ||
[[1sy6]] – hCD3 extracellular domain + antibody<BR /> | **[[1sy6]] – hCD3 extracellular domain + antibody<BR /> | ||
*CD3 εδ dimer | |||
[[1xiw]] – hCD3 extracellular domain + antibody<BR /> | **[[1xiw]] – hCD3 extracellular domain + antibody<BR /> | ||
[[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR /> | **[[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR /> | ||
*CD3 ζ chain | |||
**[[1ygr]], [[2oq1]] – hCD3 ITAM + CD45 protein tyrosine phosphatase <BR /> | |||
**[[3ik5]], [[3ioz]] – hCD3 ITAM + NEF<BR /> | |||
**[[2hac]] – hCD3 transmembrane domain - NMR<BR /> | |||
}} | |||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||