3eop: Difference between revisions

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-[[Image:3eop.png|left|200px]]
+==Crystal Structure of the DUF55 domain of human thymocyte nuclear protein 1==
+<StructureSection load='3eop' size='340' side='right' caption='[[3eop]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3eop]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EOP FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eop OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eop RCSB], [http://www.ebi.ac.uk/pdbsum/3eop PDBsum]</span></td></tr>
+</table>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eop_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Human thymocyte nuclear protein 1 contains a unique DUF55 domain consisting of 167 residues (55-221), but its cellular function remains unclear. Crystals of DUF55 belonged to the trigonal space group P3(1), but twinning caused the data to approach apparent 622 symmetry. Two data sets were collected to 2.3 A resolution. Statistical analysis confirmed that both data sets were partially twinned by tetartohedry. Tetartohedral twin fractions were estimated. After the structure had been determined, only one twofold axis of rotational pseudosymmetry was found in the crystal structure. Using the DALI program, a YTH domain, which is a potential RNA-binding domain from human YTH-domain-containing protein 2, was identified as having the most similar three-dimensional fold to that of DUF55. It is thus implied that DUF55 might be a potential RNA-related domain.
-{{STRUCTURE_3eop|  PDB=3eop  |  SCENE=  }}
+Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry.,Yu F, Song A, Xu C, Sun L, Li J, Tang L, Yu M, Yeates TO, Hu H, He J Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):212-9. Epub 2009, Feb 20. PMID:19237743<ref>PMID:19237743</ref>
-===Crystal Structure of the DUF55 domain of human thymocyte nuclear protein 1===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_19237743}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[3eop]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOP OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:019237743</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: He, J.]]
+[[Category: He, J]]
-[[Category: Hu, H.]]
+[[Category: Hu, H]]
-[[Category: Li, L.]]
+[[Category: Li, L]]
-[[Category: Song, A.]]
+[[Category: Song, A]]
-[[Category: Sun, L.]]
+[[Category: Sun, L]]
-[[Category: Tang, L.]]
+[[Category: Tang, L]]
-[[Category: Xu, C.]]
+[[Category: Xu, C]]
-[[Category: Yu, F.]]
+[[Category: Yu, F]]
 [[Category: Nucleus]]
 [[Category: Phosphoprotein]]
 [[Category: Unknown function]]