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''' | ==The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates== | ||
<StructureSection load='4nkf' size='340' side='right' caption='[[4nkf]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4nkf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NKF FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n9u|4n9u]], [[4ng6|4ng6]], [[1yq7|1yq7]], [[1zw5|1zw5]], [[4nke|4nke]], [[4nua|4nua]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nkf RCSB], [http://www.ebi.ac.uk/pdbsum/4nkf PDBsum]</span></td></tr> | |||
</table> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Barnett, B L]] | |||
[[Category: Delft, F Von]] | |||
[[Category: Dunford, J E]] | |||
[[Category: Ebetino, F H]] | |||
[[Category: Muniz, J R.C]] | |||
[[Category: Oppermann, U]] | |||
[[Category: Russell, R G.G]] | |||
[[Category: Tsoumpra, M K]] | |||
[[Category: Walter, R L]] | |||
[[Category: Alpha-helical prenyltransferase]] | |||
[[Category: Bisphosphonate]] | |||
[[Category: Cholesterol synthesis]] | |||
[[Category: Isoprene biosynthesis]] | |||
[[Category: Isoprenoid pathway]] | |||
[[Category: Lipid synthesis]] | |||
[[Category: Steroid biosynthesis]] | |||
[[Category: Transferase]] | |||
Revision as of 15:50, 19 November 2014
The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonatesThe effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
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