1l6o: Difference between revisions

Revision as of 13:27, 20 March 2008

, resolution 2.200Å

Coordinates:

XENOPUS DISHEVELLED PDZ DOMAIN

OverviewOverview

Dapper was isolated in a screen for proteins interacting with Dishevelled, a key factor in Wnt signaling. Dapper and Dishevelled colocalize intracellularly and form a complex with Axin, GSK-3, CKI, and beta-catenin. Overexpression of Dapper increases Axin and GSK-3 in this complex, resulting in decreased soluble beta-catenin and decreased activation of beta-catenin-responsive genes. Dapper also inhibits activation by Dishevelled of c-Jun N-terminal kinase (JNK), a component of beta-catenin-independent Frizzled signaling. Inhibition of Dapper activates both beta-catenin-responsive genes and an AP1-responsive promoter, demonstrating that Dapper is a general Dishevelled antagonist. Depletion of maternal Dapper RNA from Xenopus embryos results in loss of notochord and head structures, demonstrating that Dapper is required for normal vertebrate development.

About this StructureAbout this Structure

1L6O is a Protein complex structure of sequences from Xenopus laevis. Full crystallographic information is available from OCA.

ReferenceReference

Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation., Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT, Dev Cell. 2002 Apr;2(4):449-61. PMID:11970895

Page seeded by OCA on Thu Mar 20 12:27:09 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1l6o.gif|left|200px]]<br /><applet load="1l6o" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1l6o.gif|left|200px]]
-caption="1l6o, resolution 2.200&Aring;" />
-'''XENOPUS DISHEVELLED PDZ DOMAIN'''<br />
+ {{Structure
+|PDB= 1l6o |SIZE=350|CAPTION= <scene name='initialview01'>1l6o</scene>, resolution 2.200&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE=
+}}
+'''XENOPUS DISHEVELLED PDZ DOMAIN'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-L6O is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA].
+L6O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L6O OCA].
 ==Reference==
-Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation., Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT, Dev Cell. 2002 Apr;2(4):449-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11970895 11970895]
+Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation., Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT, Dev Cell. 2002 Apr;2(4):449-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11970895 11970895]
 [[Category: Protein complex]]
 [[Category: Xenopus laevis]]
@@ Line 27: / Line 36: @@
 [[Category: wnt pathway]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:41:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:27:09 2008''