Flotillin: Difference between revisions
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Flotillins, also called reggie proteins, form a family of two ubiquitously expressed and highly conserved proteins, i.e., flotillin-1 and flotillin-2. Despite being products of different genes, both flotillins have a molecular weight of approximately 48 kDa and their sequences are quite similar (50% identity on mRNA level and 44% on protein level). | Flotillins, also called reggie proteins, form a family of two ubiquitously expressed and highly conserved proteins, i.e., flotillin-1 and flotillin-2. Despite being products of different genes, both flotillins have a molecular weight of approximately 48 kDa and their sequences are quite similar (50% identity on mRNA level and 44% on protein level). | ||
Flotillins are expressed in all mammals but they are also present in bacteria, plants, fungi and metazoans, but not in the budding yeast and C. elegant. | Flotillins are expressed in all mammals but they are also present in bacteria, plants, fungi and metazoans, but not in the budding yeast and C. elegant. | ||
<scene name='60/607923/Mouse_flotillin/2'>mouse flot-2</scene> | |||
Flotillins are highly conserved among species. For example, mouse and human flotillin-1 share a 98.1% identical amino acid sequence. Even between vertebrates and invertebrates the similarity is more than 60%, implicating that flotillins are important for cell physiology. | Flotillins are highly conserved among species. For example, mouse and human flotillin-1 share a 98.1% identical amino acid sequence. Even between vertebrates and invertebrates the similarity is more than 60%, implicating that flotillins are important for cell physiology. | ||