1ksw: Difference between revisions

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[[Image:1ksw.gif|left|200px]]<br /><applet load="1ksw" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ksw.gif|left|200px]]
caption="1ksw, resolution 2.8&Aring;" />
 
'''Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP'''<br />
{{Structure
|PDB= 1ksw |SIZE=350|CAPTION= <scene name='initialview01'>1ksw</scene>, resolution 2.8&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NBS:N6-BENZYL ADENOSINE-5'-DIPHOSPHATE'>NBS</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2]
|GENE=
}}
 
'''Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1KSW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NBS:'>NBS</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSW OCA].  
1KSW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSW OCA].  


==Reference==
==Reference==
Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme., Witucki LA, Huang X, Shah K, Liu Y, Kyin S, Eck MJ, Shokat KM, Chem Biol. 2002 Jan;9(1):25-33. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11841936 11841936]
Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme., Witucki LA, Huang X, Shah K, Liu Y, Kyin S, Eck MJ, Shokat KM, Chem Biol. 2002 Jan;9(1):25-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11841936 11841936]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: bump hole]]
[[Category: bump hole]]
[[Category: bump-hole]]
[[Category: bump-hole]]
[[Category: chemical genetics]]
[[Category: chemical genetic]]
[[Category: kinase]]
[[Category: kinase]]
[[Category: orthogonal substrate]]
[[Category: orthogonal substrate]]
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[[Category: sh3]]
[[Category: sh3]]


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