1kp6: Difference between revisions
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'''USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT''' | {{Structure | ||
|PDB= 1kp6 |SIZE=350|CAPTION= <scene name='initialview01'>1kp6</scene>, resolution 1.80Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1KP6 is a [ | 1KP6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ustilago_maydis Ustilago maydis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KP6 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore., Li N, Erman M, Pangborn W, Duax WL, Park CM, Bruenn J, Ghosh D, J Biol Chem. 1999 Jul 16;274(29):20425-31. PMID:[http:// | Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore., Li N, Erman M, Pangborn W, Duax WL, Park CM, Bruenn J, Ghosh D, J Biol Chem. 1999 Jul 16;274(29):20425-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10400668 10400668] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Ustilago maydis]] | [[Category: Ustilago maydis]] | ||
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[[Category: killer toxin]] | [[Category: killer toxin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:20:21 2008'' | ||
Revision as of 13:20, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT
OverviewOverview
Ustilago maydis is a fungal pathogen of maize, some strains of which secrete killer toxins. The toxins are encoded by double-stranded RNA viruses in the cell cytoplasm. The U. maydis killer toxin KP6 contains two polypeptide chains, alpha and beta, having 79 and 81 amino acids, respectively, both of which are necessary for its killer activity. The crystal structure of the alpha-subunit of KP6 (KP6alpha) has been determined at 1.80-A resolution. KP6alpha forms a single domain structure that has an overall shape of an ellipsoid with dimensions 40 A x 26 A x 21 A and belongs to the alpha/beta-sandwich family. The tertiary structure consists of a four-stranded antiparallel beta-sheet, a pair of antiparallel alpha-helices, a short strand along one edge of the sheet, and a short N-terminal helix. Although the fold is reminiscent of toxins of similar size, the topology of KP6alpha is distinctly different in that the alpha/beta-sandwich motif has two right-handed betaalphabeta split crossovers. Monomers of KP6alpha assemble through crystallographic symmetries, forming a hexamer with a central pore lined by hydrophobic N-terminal helices. The central pore could play an important role in the mechanism of the killing action of the toxin.
About this StructureAbout this Structure
1KP6 is a Single protein structure of sequence from Ustilago maydis. Full crystallographic information is available from OCA.
ReferenceReference
Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore., Li N, Erman M, Pangborn W, Duax WL, Park CM, Bruenn J, Ghosh D, J Biol Chem. 1999 Jul 16;274(29):20425-31. PMID:10400668
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