2v01: Difference between revisions

Revision as of 18:36, 30 October 2007

RECOMBINANT VERTEBRATE CALMODULIN COMPLEXED WITH PB

OverviewOverview

Calmodulin is a calcium sensor that is also capable of binding and being, activated by other metal ions. Of specific interest in this respect is, lead, which is known to be neurotoxic and to have a very high affinity, towards calmodulin. Crystal structures of human calmodulin complexed with, lead and barium ions have been solved. The results will help in, understanding the activation mechanisms of calmodulin by different heavy, metals and will provide a detailed view of a putative target for lead, neurotoxicity in humans.

About this StructureAbout this Structure

2V01 is a [Single protein] structure of sequence from [Homo sapiens] with PB and CA as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

ReferenceReference

A structural insight into lead neurotoxicity and calmodulin activation by heavy metals., Kursula P, Majava V, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):653-6. Epub 2007 Jul 28. PMID:17671360

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OCA

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