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''' | ==Crystal structure analysis of cruzain bound to vinyl sulfone analog of WRR-483 (WRR-666)== | ||
<StructureSection load='4pi3' size='340' side='right' caption='[[4pi3]], [[Resolution|resolution]] 1.27Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4pi3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PI3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2V5:N-[(2S)-5-(CARBAMIMIDAMIDOOXY)-1-OXO-1-{[(1E,3S)-5-PHENYL-1-(PHENYLSULFONYL)PENT-1-EN-3-YL]AMINO}PENTAN-2-YL]-4-METHYLPIPERAZINE-1-CARBOXAMIDE'>2V5</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lxs|3lxs]], [[2oz2|2oz2]], [[4pi4|4pi4]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pi3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pi3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pi3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pi3 PDBsum]</span></td></tr> | |||
</table> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cruzipain]] | |||
[[Category: McKerrow, J H]] | |||
[[Category: Tochowicz, A]] | |||
[[Category: Analoge of wrr-483]] | |||
[[Category: Chagas disease]] | |||
[[Category: Covalent inhibitor]] | |||
[[Category: Cruzain]] | |||
[[Category: Cystein protease]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Vinyl sulfone derivative]] | |||
Revision as of 09:53, 12 November 2014
Crystal structure analysis of cruzain bound to vinyl sulfone analog of WRR-483 (WRR-666)Crystal structure analysis of cruzain bound to vinyl sulfone analog of WRR-483 (WRR-666)
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