VP24: Difference between revisions

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Wally Novak, Jaime Prilusky, Michal Harel

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 '''Marburg'''
-Keap1 is a protein that degrades the transcription factor Nrf2(4). VP24 in the Marburg virus targets and binds the Keap1 protein, and as a result leaves Nrf2 unaltered(4). High levels of Nrf2 triggers antioxidant response elements(ARE)(4). This causes cells to become defensive, which protects the Marburg virus inside the cell(4).
+Keap1 is a protein that degrades the transcription factor Nrf2. VP24 in the Marburg virus targets and binds the Keap1 protein, and as a result leaves Nrf2 unaltered. High levels of Nrf2 triggers antioxidant response elements(ARE). This causes cells to become defensive, which protects the Marburg virus inside the cell <ref>do 10.1016/j.celrep.2014.01.043</ref>.
 == Structural Characteristics ==
-The Ebola and Marburg VP24 proteins are 30% identical(1). They share a similar pyramidal shaped domain, as well as a few structures. Both viruses have two highly conserved pockets underneath the "pyramid's" base <ref name='Marburg '/>. Additionally, the N termini of Ebola (Zaire) and the Marburg virus are very similar in function. They are both used for oligomer and nucleocapsid formation <ref name='Marburg '/><ref>pmid 22371572</ref>.
+The Ebola and Marburg VP24 proteins are 30% identical <ref name='Marburg '/>. They share a similar pyramidal shaped domain, as well as a few structures. Both viruses have two highly conserved pockets underneath the "pyramid's" base <ref name='Marburg '/>. Additionally, the N termini of Ebola (Zaire) and the Marburg virus are very similar in function. They are both used for oligomer and nucleocapsid formation <ref name='Marburg '/><ref>pmid 22371572</ref>.
 <scene name='60/602719/Chain_b/1'>Ebola Domain</scene> (Reston)