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==Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-GalNAc derived inhibitor (3GW and 4GW)== | |||
<StructureSection load='3v0n' size='340' side='right' caption='[[3v0n]], [[Resolution|resolution]] 1.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3v0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V0N FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3GW:5-(5-FORMYLTHIOPHEN-2-YL)URIDINE-5(2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GALACTOSYL)-DIPHOSPHATE'>3GW</scene>, <scene name='pdbligand=4GW:5-(5-FORMYLTHIOPHEN-2-YL)URIDINE+5-(TRIHYDROGEN+DIPHOSPHATE)'>4GW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ioh|3ioh]], [[3ioi|3ioi]], [[3ioj|3ioj]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AB0, ABO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v0n RCSB], [http://www.ebi.ac.uk/pdbsum/3v0n PDBsum]</span></td></tr> | ||
[[3v0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0N OCA]. | </table> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Jorgensen, R.]] | [[Category: Jorgensen, R.]] | ||
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[[Category: Manganese]] | [[Category: Manganese]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: | [[Category: Rossmann fold]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Signal-anchor]] | [[Category: Signal-anchor]] | ||
Revision as of 17:01, 3 November 2014
Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-GalNAc derived inhibitor (3GW and 4GW)Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-GalNAc derived inhibitor (3GW and 4GW)
Structural highlights
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