365d: Difference between revisions
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[[ | ==STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE== | ||
<StructureSection load='365d' size='340' side='right' caption='[[365d]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[365d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=365D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=365D FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IIP:IMIDAZOLE-PYRROLE+POLYAMIDE'>IIP</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=365d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=365d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=365d RCSB], [http://www.ebi.ac.uk/pdbsum/365d PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Small molecules that target specific DNA sequences offer a potentially general approach for the regulation of gene expression. Pyrrole-imidazole polyamides represent the only class of synthetic small molecules that can bind predetermined DNA sequences with affinities and specificities comparable to DNA binding proteins. Antiparallel side-by-side pairings of two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C from C.G, and both from A.T/T.A base pairs. A high resolution X-ray crystal structure of a four-ring pyrrole-imidazole polyamide specifically bound as a dimer to a six-base pair predetermined DNA site reveals a structural framework of hydrogen bonds and interactions with the walls of the minor groove that underlies the pairing rules for DNA recognition. | |||
Structural basis for G.C recognition in the DNA minor groove.,Kielkopf CL, Baird EE, Dervan PB, Rees DC Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:9461074<ref>PMID:9461074</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Baird, E E.]] | [[Category: Baird, E E.]] | ||
[[Category: Dervan, P B.]] | [[Category: Dervan, P B.]] | ||
Revision as of 14:55, 29 October 2014
STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVESTRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE
Structural highlights
Publication Abstract from PubMedSmall molecules that target specific DNA sequences offer a potentially general approach for the regulation of gene expression. Pyrrole-imidazole polyamides represent the only class of synthetic small molecules that can bind predetermined DNA sequences with affinities and specificities comparable to DNA binding proteins. Antiparallel side-by-side pairings of two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C from C.G, and both from A.T/T.A base pairs. A high resolution X-ray crystal structure of a four-ring pyrrole-imidazole polyamide specifically bound as a dimer to a six-base pair predetermined DNA site reveals a structural framework of hydrogen bonds and interactions with the walls of the minor groove that underlies the pairing rules for DNA recognition. Structural basis for G.C recognition in the DNA minor groove.,Kielkopf CL, Baird EE, Dervan PB, Rees DC Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:9461074[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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