1k09: Difference between revisions

Revision as of 13:10, 20 March 2008

Ligands:

Coordinates:

Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein

OverviewOverview

BetaCore is a designed approximately 50-residue protein in which two BPTI-derived core modules, CM I and CM II, are connected by a 22-atom cross-link. At low temperature and pH 3, homo- and heteronuclear NMR data report a dominant folded ('f') conformation with well-dispersed chemical shifts, i, i+1 periodicity, numerous long-range NOEs, and slowed amide hydrogen isotope exchange patterns that is a four-stranded antiparallel beta-sheet with nonsymmetrical and specific association of CM I and CM II. BetaCore 'f' conformations undergo reversible, global, moderately cooperative, non-two-state thermal transitions to an equilibrium ensemble of unfolded 'u' conformations. There is a significant energy barrier between 'f' and 'u' conformations. This is the first designed four-stranded antiparallel beta-sheet that folds in water.

About this StructureAbout this Structure

1K09 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

ReferenceReference

BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein., Carulla N, Woodward C, Barany G, Protein Sci. 2002 Jun;11(6):1539-51. PMID:12021452

Page seeded by OCA on Thu Mar 20 12:10:50 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1k09.jpg|left|200px]]<br /><applet load="1k09" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1k09.jpg|left|200px]]
-caption="1k09" />
-'''Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein'''<br />
+ {{Structure
+|PDB= 1k09 |SIZE=350|CAPTION= <scene name='initialview01'>1k09</scene>
+|SITE=
+|LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-K09 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NH2:'>NH2</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K09 OCA].
+K09 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K09 OCA].
 ==Reference==
-BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein., Carulla N, Woodward C, Barany G, Protein Sci. 2002 Jun;11(6):1539-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12021452 12021452]
+BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein., Carulla N, Woodward C, Barany G, Protein Sci. 2002 Jun;11(6):1539-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12021452 12021452]
 [[Category: Protein complex]]
 [[Category: Barany, G.]]
@@ Line 18: / Line 27: @@
 [[Category: four-stranded antiparallel beta-sheet]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:28:42 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:10:50 2008''