1k05: Difference between revisions
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'''Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase''' | {{Structure | ||
|PDB= 1k05 |SIZE=350|CAPTION= <scene name='initialview01'>1k05</scene>, resolution 2.9Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] | |||
|GENE= FAK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1K05 is a [ | 1K05 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K05 OCA]. | ||
==Reference== | ==Reference== | ||
The structural basis of localization and signaling by the focal adhesion targeting domain., Arold ST, Hoellerer MK, Noble ME, Structure. 2002 Mar;10(3):319-27. PMID:[http:// | The structural basis of localization and signaling by the focal adhesion targeting domain., Arold ST, Hoellerer MK, Noble ME, Structure. 2002 Mar;10(3):319-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12005431 12005431] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: up-down-up-down four helical bundle]] | [[Category: up-down-up-down four helical bundle]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:10:45 2008'' | ||
Revision as of 13:10, 20 March 2008
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| , resolution 2.9Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | FAK (Homo sapiens) | ||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase
OverviewOverview
The localization of focal adhesion kinase (FAK) to sites of integrin clustering initiates downstream signaling. The C-terminal focal adhesion targeting (FAT) domain causes this localization by interacting with talin and paxillin. FAT also mediates signaling through Grb2 via phosphorylated Y925. We report two crystal structures of the FAT domain. Large rearrangements of the structure are indicated to allow phosphorylation of Y925 and subsequent interaction with Grb2. Sequence homology and structural compatibility suggest a FAT-like fold for the C-terminal domains of CAS, Efs/Sin, and HEF1. A structure-based alignment including these proteins and the vinculin tail domain reveals a conserved region that could play a role in focal adhesion targeting. Previously postulated "paxillin binding subdomains" may contribute to structural integrity rather than directly to paxillin binding.
About this StructureAbout this Structure
1K05 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The structural basis of localization and signaling by the focal adhesion targeting domain., Arold ST, Hoellerer MK, Noble ME, Structure. 2002 Mar;10(3):319-27. PMID:12005431
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