1jwz: Difference between revisions

No edit summary
No edit summary
Line 1: Line 1:
[[Image:1jwz.jpg|left|200px]]<br /><applet load="1jwz" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1jwz.jpg|left|200px]]
caption="1jwz, resolution 1.80&Aring;" />
 
'''Crystal structure of TEM-64 beta-lactamase in complex with a boronic acid inhibitor (105)'''<br />
{{Structure
|PDB= 1jwz |SIZE=350|CAPTION= <scene name='initialview01'>1jwz</scene>, resolution 1.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=105:N-[5-METHYL-3-O-TOLYL-ISOXAZOLE-4-CARBOXYLIC ACID AMIDE] BORONIC ACID'>105</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE= bla ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''Crystal structure of TEM-64 beta-lactamase in complex with a boronic acid inhibitor (105)'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
1JWZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=105:'>105</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWZ OCA].  
1JWZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWZ OCA].  


==Reference==
==Reference==
Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs., Wang X, Minasov G, Shoichet BK, J Mol Biol. 2002 Jun 28;320(1):85-95. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12079336 12079336]
Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs., Wang X, Minasov G, Shoichet BK, J Mol Biol. 2002 Jun 28;320(1):85-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12079336 12079336]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
Line 25: Line 34:
[[Category: tem-64]]
[[Category: tem-64]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:27:39 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:09:38 2008''

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA