VP24: Difference between revisions
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'''Ebola''' | '''Ebola''' | ||
In a normal immune response interferons (IFN) are produced to alert surrounding cells to the presence of a pathogen, which activates STAT1 by phosphorylation(2). STAT1 is a transcription factor that increases production of immune fighting genes in cells, STAT1 is brought to the nucleus by karyopherin α proteins(2). Ebola protein VP24 | In a normal immune response interferons (IFN) are produced to alert surrounding cells to the presence of a pathogen, which activates STAT1 by phosphorylation(2). STAT1 is a transcription factor that increases production of immune fighting genes in cells, STAT1 is brought to the nucleus by karyopherin α proteins(2). Ebola protein VP24 <scene name='60/602719/Vp24_bound_to_karyopherin_a5/1'>binds to karyopherin</scene> α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus(3). As a result, the immune response in cells is greatly weakened(3). | ||
<scene name='60/602719/Vp24_bound_to_karyopherin_a5/1'>binds to karyopherin</scene> α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus(3). As a result, the immune response in cells is greatly weakened(3). | |||
'''Marburg''' | '''Marburg''' | ||