VP24: Difference between revisions
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In a normal immune response interferons (IFN) are produced to alert surrounding cells to the presence of a pathogen. This response activates STAT1 by phosphorylation. STAT1 is a transcription factor that increases production of immune fighting genes in cells, STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 | In a normal immune response interferons (IFN) are produced to alert surrounding cells to the presence of a pathogen. This response activates STAT1 by phosphorylation. STAT1 is a transcription factor that increases production of immune fighting genes in cells, STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 | ||
<scene name='60/602719/Vp24_bound_to_karyopherin_a5/1'> binds to karyopherin α5 </scene> | <scene name='60/602719/Vp24_bound_to_karyopherin_a5/1'>binds to karyopherin α5</scene> | ||
</StructureSection> α1, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result, the immune response in cells is then greatly weakened. | </StructureSection> α1, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result, the immune response in cells is then greatly weakened. | ||