VP24: Difference between revisions
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== Structural Characteristics == | == Structural Characteristics == | ||
The Ebola and Marburg VP24 proteins are 30% identical. They share a similar pyramidal shape, as well as a few structures. Both viruses have two highly conserved pockets underneath the "pyramid's" base. Additionally, the N termini of Ebola (Zaire) and the Marburg virus are very similar. | The Ebola and Marburg VP24 proteins are 30% identical. They share a similar pyramidal shape, as well as a few structures. Both viruses have two highly conserved pockets underneath the "pyramid's" base. Additionally, the N termini of Ebola (Zaire) and the Marburg virus are very similar in function. They are used by the for proper nucleocapsid functioning. | ||
<scene name='60/602719/Reston_vp24/1'>Ebola Structure</scene> (Reston) | <scene name='60/602719/Reston_vp24/1'>Ebola Structure</scene> (Reston) | ||
There are a few structural characteristics only found in the Ebola viruses. At the top of the pyramidal domain, there are α helices present which are thought to interact with the α karyopherin. | |||
<scene name='60/602719/Marburg_vp24/1'>Marburg Structure</scene> | <scene name='60/602719/Marburg_vp24/1'>Marburg Structure</scene> | ||