VP24: Difference between revisions
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== Structural Characteristics == | == Structural Characteristics == | ||
The ebola and marburg | The ebola and marburg VP24 proteins are 30% identical. | ||
<scene name='60/602719/Reston_vp24/1'>Ebola Structure</scene> (Reston) | <scene name='60/602719/Reston_vp24/1'>Ebola Structure</scene> (Reston) | ||
Revision as of 21:04, 13 October 2014
VP24VP24
IntroductionVP24 is a protein present in the ebola and marburg viruses, both of which are members of Filoviridae family. Presently there are five strains of ebola: Sudan, Reston, Zire, Bundibugyo, and Taï Forest, each with minor differences in VP24 sequences(3). The marburg virus has only one strain. FunctionEbola In a normal immune response interferons (IFN) are produced to alert surrounding cells of the presence of a pathogen. This response activates STAT1, which increases production of immune fighting genes in cells, by phosphorylation. STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result the immune response in cells is then greatly weakened. The Reston strain is not immuno_____, unlike the other four. Marburg
Structural CharacteristicsThe ebola and marburg VP24 proteins are 30% identical. (Reston) VP24 is crucial for proper functioni of the viral nucleoprotein
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