1jm7: Difference between revisions
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[[Image:1jm7.gif|left|200px]]< | [[Image:1jm7.gif|left|200px]] | ||
'''Solution structure of the BRCA1/BARD1 RING-domain heterodimer''' | {{Structure | ||
|PDB= 1jm7 |SIZE=350|CAPTION= <scene name='initialview01'>1jm7</scene> | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | |||
|ACTIVITY= | |||
|GENE= BRCA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BARD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Solution structure of the BRCA1/BARD1 RING-domain heterodimer''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1JM7 is a [ | 1JM7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JM7 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of a BRCA1-BARD1 heterodimeric RING-RING complex., Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE, Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:[http:// | Structure of a BRCA1-BARD1 heterodimeric RING-RING complex., Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE, Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11573085 11573085] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: zinc-binding protein]] | [[Category: zinc-binding protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:05:18 2008'' | ||
Revision as of 13:05, 20 March 2008
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| Ligands: | |||||||
| Gene: | BRCA1 (Homo sapiens), BARD1 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the BRCA1/BARD1 RING-domain heterodimer
OverviewOverview
The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. We present the solution structure of the heterodimer formed between the RING domains of BRCA1 and BARD1. Comparison with the RING homodimer of the V(D)J recombination-activating protein RAG1 reveals the structural diversity of complexes formed by interactions between different RING domains. The BRCA1-BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCA1 RING domain can be involved in associations with multiple protein partners and provides a framework for understanding cancer-causing mutations at the molecular level.
DiseaseDisease
Known diseases associated with this structure: Breast cancer, susceptibility to OMIM:[601593], Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705]
About this StructureAbout this Structure
1JM7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure of a BRCA1-BARD1 heterodimeric RING-RING complex., Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE, Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085
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