1jh5: Difference between revisions
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[[Image:1jh5.gif|left|200px]] | [[Image:1jh5.gif|left|200px]] | ||
'''Crystal Structure of sTALL-1 of TNF family ligand''' | {{Structure | ||
|PDB= 1jh5 |SIZE=350|CAPTION= <scene name='initialview01'>1jh5</scene>, resolution 3.00Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
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'''Crystal Structure of sTALL-1 of TNF family ligand''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1JH5 is a [ | 1JH5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JH5 OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands., Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G, Cell. 2002 Feb 8;108(3):383-94. PMID:[http:// | Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands., Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G, Cell. 2002 Feb 8;108(3):383-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11853672 11853672] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Zhang, G.]] | [[Category: Zhang, G.]] | ||
[[Category: baff]] | [[Category: baff]] | ||
[[Category: | [[Category: bly]] | ||
[[Category: tall-1]] | [[Category: tall-1]] | ||
[[Category: thank]] | [[Category: thank]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:03:19 2008'' | ||
Revision as of 13:03, 20 March 2008
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Crystal Structure of sTALL-1 of TNF family ligand
OverviewOverview
TALL-1/BAFF/BLyS was recently identified as a member of the tumor necrosis factor (TNF) ligand family. The crystal structure of the functional soluble TALL-1 (sTALL-1) has been determined at 3.0 A. sTALL-1 forms a virus-like assembly with 200 A diameter in the crystals, containing 60 sTALL-1 monomers. The cluster formation is mediated by a "flap" region of the sTALL-1 monomer. The virus-like assembly was also detected in solution using gel filtration and electron microscopy. Deletion of the flap region disrupted the formation of the virus-like assembly. The mutant sTALL-1 still bound its receptor but could not activate NF-kappaB and did not stimulate B lymphocyte proliferation. Finally, we found the virus-like cluster of sTALL-1 exists in physiological condition. We propose that this virus-like assembly of sTALL-1 is the functional unit for TALL-1 in vivo.
About this StructureAbout this Structure
1JH5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands., Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G, Cell. 2002 Feb 8;108(3):383-94. PMID:11853672
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