1jfp: Difference between revisions

Revision as of 13:02, 20 March 2008

Ligands:

Coordinates:

Structure of bovine rhodopsin (dark adapted)

OverviewOverview

Activation of G-protein coupled receptors (GPCR) is not yet understood. A recent structure showed most of rhodopsin in the ground (not activated) state of the GPCR, but the cytoplasmic face, which couples to the G protein in signal transduction, was not well-defined. We have determined an experimental three-dimensional structure for rhodopsin in the unactivated state, which shows good agreement with the crystal structure in the transmembrane domain. This new structure defines the cytoplasmic face of rhodopsin. The G-protein binding site can be mapped. The same experimental approach yields a preliminary structure of the cytoplasmic face in the activated (metarhodopsin II) receptor. Differences between the two structures suggest how the receptor is activated to couple with transducin.

About this StructureAbout this Structure

1JFP is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms., Yeagle PL, Choi G, Albert AD, Biochemistry. 2001 Oct 2;40(39):11932-7. PMID:11570894

Page seeded by OCA on Thu Mar 20 12:02:52 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1jfp.jpg|left|200px]]<br /><applet load="1jfp" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1jfp.jpg|left|200px]]
-caption="1jfp" />
-'''Structure of bovine rhodopsin (dark adapted)'''<br />
+ {{Structure
+|PDB= 1jfp |SIZE=350|CAPTION= <scene name='initialview01'>1jfp</scene>
+|SITE=
+|LIGAND= <scene name='pdbligand=RET:RETINAL'>RET</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''Structure of bovine rhodopsin (dark adapted)'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-JFP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=RET:'>RET</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA].
+JFP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA].
 ==Reference==
-Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms., Yeagle PL, Choi G, Albert AD, Biochemistry. 2001 Oct 2;40(39):11932-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11570894 11570894]
+Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms., Yeagle PL, Choi G, Albert AD, Biochemistry. 2001 Oct 2;40(39):11932-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11570894 11570894]
 [[Category: Bos taurus]]
 [[Category: Single protein]]
@@ Line 19: / Line 28: @@
 [[Category: g-protein coupled receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:02:52 2008''