1izh: Difference between revisions

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OCA

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-[[Image:1izh.gif|left|200px]]<br /><applet load="1izh" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1izh.gif|left|200px]]
-caption="1izh, resolution 1.90&Aring;" />
-'''Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants'''<br />
+ {{Structure
+|PDB= 1izh |SIZE=350|CAPTION= <scene name='initialview01'>1izh</scene>, resolution 1.90&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=Q50:{(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC ACID TERT-BUTYL ESTER'>Q50</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
+|GENE=
+}}
+'''Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-IZH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=Q50:'>Q50</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZH OCA].
+IZH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZH OCA].
 ==Reference==
-Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains., Weber J, Mesters JR, Lepsik M, Prejdova J, Svec M, Sponarova J, Mlcochova P, Skalicka K, Strisovsky K, Uhlikova T, Soucek M, Machala L, Stankova M, Vondrasek J, Klimkait T, Kraeusslich HG, Hilgenfeld R, Konvalinka J, J Mol Biol. 2002 Dec 6;324(4):739-54. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12460574 12460574]
+Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains., Weber J, Mesters JR, Lepsik M, Prejdova J, Svec M, Sponarova J, Mlcochova P, Skalicka K, Strisovsky K, Uhlikova T, Soucek M, Machala L, Stankova M, Vondrasek J, Klimkait T, Kraeusslich HG, Hilgenfeld R, Konvalinka J, J Mol Biol. 2002 Dec 6;324(4):739-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12460574 12460574]
 [[Category: HIV-1 retropepsin]]
 [[Category: Human immunodeficiency virus 1]]
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 [[Category: subsite binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:17:21 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:56:58 2008''