1itb: Difference between revisions
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[[Image:1itb.gif|left|200px]] | [[Image:1itb.gif|left|200px]] | ||
'''TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA''' | {{Structure | ||
|PDB= 1itb |SIZE=350|CAPTION= <scene name='initialview01'>1itb</scene>, resolution 2.5Å | |||
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|LIGAND= | |||
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'''TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1ITB is a [ | 1ITB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ITB OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta., Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ, Nature. 1997 Mar 13;386(6621):190-4. PMID:[http:// | Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta., Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ, Nature. 1997 Mar 13;386(6621):190-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9062193 9062193] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:54:40 2008'' | ||
Revision as of 12:54, 20 March 2008
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TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA
OverviewOverview
Interleukin-1 (IL-1) is an important mediator of inflammatory disease. The IL-1 family currently consists of two agonists, IL-1alpha and IL-1beta, and one antagonist, IL-1ra. Each of these molecules binds to the type I IL-1 receptor (IL1R). The binding of IL-1alpha or IL-1beta to IL1R is an early step in IL-1 signal transduction and blocking this interaction may therefore be a useful target for the development of new drugs. Here we report the three-dimensional structure of IL-1beta bound to the extracellular domain of IL1R (s-IL1R) at 2.5 A resolution. IL-1beta binds to s-IL1R with a 1:1 stoichiometry. The crystal structure shows that s-IL1R consists of three immunoglobulin-like domains which wrap around IL-1beta in a manner distinct from the structures of previously described cytokine-receptor complexes. The two receptor-binding regions on IL-1beta identified by site-directed mutagenesis both contact the receptor: one binds to the first two domains of the receptor, while the other binds exclusively to the third domain.
DiseaseDisease
Known diseases associated with this structure: Gastric cancer risk after H. pylori infection OMIM:[147720], Mental retardation, X-linked, 21/34 OMIM:[300206]
About this StructureAbout this Structure
1ITB is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta., Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ, Nature. 1997 Mar 13;386(6621):190-4. PMID:9062193
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