4c49: Difference between revisions

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'''Unreleased structure'''
==Reactive loop cleaved human CBG in complex with cortisol==
 
<StructureSection load='4c49' size='340' side='right' caption='[[4c49]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
The entry 4c49 is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4c49]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C49 FirstGlance]. <br>
Authors: Chan, W.L., Zhou, A., Read, R.J.
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HCY:(11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE'>HCY</scene><br>
 
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c41|4c41]]</td></tr>
Description: Reactive loop cleaved human CBG in complex with cortisol
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c49 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c49 RCSB], [http://www.ebi.ac.uk/pdbsum/4c49 PDBsum]</span></td></tr>
<table>
== Disease ==
[[http://www.uniprot.org/uniprot/CBG_HUMAN CBG_HUMAN]] Corticosteroid-binding globulin deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/CBG_HUMAN CBG_HUMAN]] Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.<ref>PMID:18513745</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chan, W L.]]
[[Category: Read, R J.]]
[[Category: Zhou, A.]]
[[Category: Corticosteroid binding globulin]]
[[Category: Hormone carrier]]
[[Category: Serpin]]
[[Category: Transport protein]]

Revision as of 03:20, 2 October 2014

Reactive loop cleaved human CBG in complex with cortisolReactive loop cleaved human CBG in complex with cortisol

Structural highlights

4c49 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:4c41
Resources:FirstGlance, OCA, RCSB, PDBsum

Disease

[CBG_HUMAN] Corticosteroid-binding globulin deficiency. The disease is caused by mutations affecting the gene represented in this entry.

Function

[CBG_HUMAN] Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.[1]

References

  1. ↑ Zhou A, Wei Z, Stanley PL, Read RJ, Stein PE, Carrell RW. The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release. J Mol Biol. 2008 Jun 27;380(1):244-51. Epub 2008 May 14. PMID:18513745 doi:10.1016/j.jmb.2008.05.012

4c49, resolution 2.70Å

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