1ifa: Difference between revisions

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File:1ifa.jpg

, resolution 2.6Å

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THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA

OverviewOverview

The crystal structure of recombinant murine interferon-beta (IFN-beta) has been solved by the multiple isomorphous replacement method and refined to an R-factor of 20.5% against 2.6 A X-ray diffraction data. The structure shows a variant of the alpha-helix bundle with a new chain-folding topology, which seems to represent a basic structural framework of all the IFN-alpha and IFN-beta molecules belonging to the type I family. Functionally important segments of the polypeptide chain, as implied through numerous gene manipulation studies carried out so far, are spatially clustered indicating the binding site(s) to the receptor(s). Comparison of the present structure with those of other alpha-helical cytokine proteins, including porcine growth hormone, interleukin 2 and interferon gamma, indicated either a topological similarity in chain folding or a similar spatial arrangement of the alpha-helices.

About this StructureAbout this Structure

1IFA is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Three-dimensional crystal structure of recombinant murine interferon-beta., Senda T, Shimazu T, Matsuda S, Kawano G, Shimizu H, Nakamura KT, Mitsui Y, EMBO J. 1992 Sep;11(9):3193-201. PMID:1505514

Page seeded by OCA on Thu Mar 20 11:49:40 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1ifa.jpg|left|200px]]<br /><applet load="1ifa" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ifa.jpg|left|200px]]
-caption="1ifa, resolution 2.6&Aring;" />
-'''THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA'''<br />
+ {{Structure
+|PDB= 1ifa |SIZE=350|CAPTION= <scene name='initialview01'>1ifa</scene>, resolution 2.6&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-IFA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ASN:'>ASN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IFA OCA].
+IFA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IFA OCA].
 ==Reference==
-Three-dimensional crystal structure of recombinant murine interferon-beta., Senda T, Shimazu T, Matsuda S, Kawano G, Shimizu H, Nakamura KT, Mitsui Y, EMBO J. 1992 Sep;11(9):3193-201. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1505514 1505514]
+Three-dimensional crystal structure of recombinant murine interferon-beta., Senda T, Shimazu T, Matsuda S, Kawano G, Shimizu H, Nakamura KT, Mitsui Y, EMBO J. 1992 Sep;11(9):3193-201. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1505514 1505514]
 [[Category: Mus musculus]]
 [[Category: Single protein]]
@@ Line 22: / Line 31: @@
 [[Category: glycoprotein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:11:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:49:40 2008''