1ido: Difference between revisions

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, resolution 1.7Å

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I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND

OverviewOverview

We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule. We suggest that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain. Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs.

About this StructureAbout this Structure

1IDO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:7867070

Page seeded by OCA on Thu Mar 20 11:48:59 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:1ido.gif|left|200px]]<br /><applet load="1ido" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ido.gif|left|200px]]
-caption="1ido, resolution 1.7&Aring;" />
-'''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND'''<br />
+ {{Structure
+|PDB= 1ido |SIZE=350|CAPTION= <scene name='initialview01'>1ido</scene>, resolution 1.7&Aring;
+|SITE= <scene name='pdbsite=MG:Metal+Binding+Site.+This+Site+Also+Includes+GLU+314+From+...'>MG</scene>
+|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-IDO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=MG:Metal+Binding+Site.+This+Site+Also+Includes+GLU+314+From+...'>MG</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IDO OCA].
+IDO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IDO OCA].
 ==Reference==
-Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7867070 7867070]
+Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7867070 7867070]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 22: / Line 31: @@
 [[Category: integrin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:48:59 2008''