Gramicidin Channel in Lipid Bilayer: Difference between revisions
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<li>Water passes | <li>Water passes | ||
<scene name='38/388981/Gramicidin_redo/ | <scene name='38/388981/Gramicidin_redo/6' oldname='User:Eric_Martz/Sandbox_10/Hydrated_bilayer_w_gramicidin/3'>through the channel</scene>. | ||
''Toggle spin off to see transparency.'' | ''Toggle spin off to see transparency.'' | ||
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Show <scene name='User:Eric_Martz/Sandbox_10/Hydrated_bilayer_w_gramicidin/4'>only water</scene>. | Show <scene name='38/388981/Gramicidin_redo/7' oldname='User:Eric_Martz/Sandbox_10/Hydrated_bilayer_w_gramicidin/4'>only water</scene>. | ||
</li><li> | </li><li> | ||
Show only | Show only | ||
Revision as of 01:36, 30 September 2014
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We apologize, but most of the scenes (green links) on this page are broken. We are working to repair this page. Eric Martz 03:07, 16 August 2014 (IDT) |
Two copies of the 15-amino-acid gramicidin peptide are shown here () arranged as they are believed to be when they form a channel through a lipid bilayer membrane[1]. The shape of the protein is shown with tiny dots, inside of which is a ribbon backbone trace connecting the alpha carbon atoms of each amino acid chain.
- Show of the gramicidin protein chains. The chains are covalently linked with dioxane in this experiment (C, O),
- (Most hydrogen atoms are omitted.)
- Show . Notice how the hydrophobic lipid "tails" exclude water.
- Water passes . Toggle spin off to see transparency.
- Show .
- Show only . For an explanation of their structure, see the detailed tutorial, also disponible en español.
| Remember to use the popup button and then resize the popup window to enlarge the molecular scenes. |
See AlsoSee Also
- A detailed explanation and tutorial about Lipid Bilayers and the Gramicidin Channel.
- This model in FirstGlance in Jmol. Be sure to click the Ligands+ and Water buttons!
- BioMolecular Explorer 3D, a resource for high school teachers that includes a section on gramicidin in a lipid bilayer.
- High school teachers' resources
- The Spanish version of this page: Canal de gramicidina en bicapa lipídica (Spanish)
- For additional information, see: Membrane Channels & Pumps
NotesNotes
- The PDB file shown here, File:Gramicidin in bilayer.pdb.gz, was kindly provided by Serge Crouzy[1].
- To load the scenes on this page into the SAT, change the page name to User:Eric_Martz/Sandbox_10, where these scenes were developed.
ReferencesReferences
- ↑ 1.0 1.1 1.2 Crouzy S, Woolf TB, Roux B. A molecular dynamics study of gating in dioxolane-linked gramicidin A channels. Biophys J. 1994 Oct;67(4):1370-86. PMID:7529578 doi:http://dx.doi.org/10.1016/S0006-3495(94)80618-6