1ujl: Difference between revisions

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-{{STRUCTURE_1ujl|  PDB=1ujl  |  SCENE=  }}
+==Solution Structure of the HERG K+ channel S5-P extracellular linker==
-===Solution Structure of the HERG K+ channel S5-P extracellular linker===
+<StructureSection load='1ujl' size='340' side='right' caption='[[1ujl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-{{ABSTRACT_PUBMED_13680209}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1ujl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UJL FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ujl RCSB], [http://www.ebi.ac.uk/pdbsum/1ujl PDBsum]</span></td></tr>
+<table>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uj/1ujl_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The HERG K+ channel has very unusual kinetic behaviour that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarisation as well as in preventing lethal ventricular arrhythmias. Extensive mutagenesis of the HERG K+ channel has allowed identification of which regions of the channel are important for the unusual kinetic behaviour of the channel. Furthermore, structural studies on scorpion toxins that potently inhibit HERG are beginning to provide clues as to the structural differences between HERG and other voltage-gated K+ channels.
-==About this Structure==
+The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics.,Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW Eur Biophys J. 2004 Apr;33(2):89-97. Epub 2003 Sep 10. PMID:13680209<ref>PMID:13680209</ref>
-[[1ujl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJL OCA].
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
 ==See Also==
 *[[Potassium Channel|Potassium Channel]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:013680209</ref><references group="xtra"/><references/>
+__TOC__
+</StructureSection>
 [[Category: Alewood, P F.]]
 [[Category: Bansal, P S.]]