1h8t: Difference between revisions

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Revision as of 12:33, 20 March 2008

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ECHOVIRUS 11

OverviewOverview

We have used X-ray crystallography to determine the structure of a decay accelerating factor (DAF)-binding, clinic-derived isolate of echovirus 11 (EV11-207). The structures of the capsid proteins closely resemble those of capsid proteins of other picornaviruses. The structure allows us to interpret a series of amino acid changes produced by passaging EV11-207 in different cell lines as highlighting the locations of multiple receptor-binding sites on the virion surface. We suggest that a DAF-binding site is located at the fivefold axes of the virion, while the binding site for a distinct but as yet unidentified receptor is located within the canyon surrounding the virion fivefold axes.

About this StructureAbout this Structure

1H8T is a Protein complex structure of sequences from Human echovirus 25. Full crystallographic information is available from OCA.

ReferenceReference

Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection., Stuart AD, McKee TA, Williams PA, Harley C, Shen S, Stuart DI, Brown TD, Lea SM, J Virol. 2002 Aug;76(15):7694-704. PMID:12097583

Page seeded by OCA on Thu Mar 20 11:33:49 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1h8t.jpg|left|200px]]<br /><applet load="1h8t" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1h8t.jpg|left|200px]]
-caption="1h8t, resolution 2.90&Aring;" />
-'''ECHOVIRUS 11'''<br />
+ {{Structure
+|PDB= 1h8t |SIZE=350|CAPTION= <scene name='initialview01'>1h8t</scene>, resolution 2.90&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=DOA:12-AMINO-DODECANOIC+ACID'>DOA</scene> and <scene name='pdbligand=MYR:MYRISTIC ACID'>MYR</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''ECHOVIRUS 11'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-H8T is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_echovirus_25 Human echovirus 25] with <scene name='pdbligand=DOA:'>DOA</scene> and <scene name='pdbligand=MYR:'>MYR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8T OCA].
+H8T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_echovirus_25 Human echovirus 25]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8T OCA].
 ==Reference==
-Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection., Stuart AD, McKee TA, Williams PA, Harley C, Shen S, Stuart DI, Brown TD, Lea SM, J Virol. 2002 Aug;76(15):7694-704. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12097583 12097583]
+Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection., Stuart AD, McKee TA, Williams PA, Harley C, Shen S, Stuart DI, Brown TD, Lea SM, J Virol. 2002 Aug;76(15):7694-704. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12097583 12097583]
 [[Category: Human echovirus 25]]
 [[Category: Protein complex]]
@@ Line 25: / Line 34: @@
 [[Category: icosahedral virus]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:58:41 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:33:49 2008''