2j7l: Difference between revisions
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Revision as of 18:21, 30 October 2007
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E.COLI P PILUS CHAPERONE PAPD IN COMPLEX WITH A PILUS BIOGENESIS INHIBITOR, PILICIDE 2C
OverviewOverview
A chemical synthesis platform with broad applications and flexibility was, rationally designed to inhibit biogenesis of adhesive pili assembled by, the chaperone-usher pathway in Gram-negative pathogens. The activity of a, family of bicyclic 2-pyridones, termed pilicides, was evaluated in two, different pilus biogenesis systems in uropathogenic Escherichia coli., Hemagglutination mediated by either type 1 or P pili, adherence to bladder, cells, and biofilm formation mediated by type 1 pili were all reduced by, approximately 90% in laboratory and clinical E. coli strains. The, structure of the pilicide bound to the P pilus chaperone PapD revealed, that the pilicide bound to the surface of the chaperone known to interact, with the usher, the outer-membrane assembly platform where pili are, ... [(full description)]
About this StructureAbout this Structure
2J7L is a [Single protein] structure of sequence from [Escherichia coli] with XC2 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria., Pinkner JS, Remaut H, Buelens F, Miller E, Aberg V, Pemberton N, Hedenstrom M, Larsson A, Seed P, Waksman G, Hultgren SJ, Almqvist F, Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17897-902. Epub 2006 Nov 10. PMID:17098869
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