1gue: Difference between revisions

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File:1gue.gif

, resolution 2.27Å

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SENSORY RHODOPSIN II

OverviewOverview

Sensory rhodopsins are the primary receptors of vision in animals and phototaxis in microorganisms. Light triggers the rapid isomerization of a buried retinal chromophore, which the protein both accommodates and amplifies into the larger structural rearrangements required for signaling. We trapped an early intermediate of the photocycle of sensory rhodopsin II from Natronobacterium pharaonis (pSRII) in 3D crystals and determined its X-ray structure to 2.3 A resolution. The observed structural rearrangements were localized near the retinal chromophore, with a key water molecule becoming disordered and the retinal's beta-ionone ring undergoing a prominent movement. Comparison with the early structural rearrangements of bacteriorhodopsin illustrates how modifications in the retinal binding pocket of pSRII allow subtle differences in the early relaxation of photoisomerized retinal.

About this StructureAbout this Structure

1GUE is a Single protein structure of sequence from Natronomonas pharaonis. Full crystallographic information is available from OCA.

ReferenceReference

Early structural rearrangements in the photocycle of an integral membrane sensory receptor., Edman K, Royant A, Nollert P, Maxwell CA, Pebay-Peyroula E, Navarro J, Neutze R, Landau EM, Structure. 2002 Apr;10(4):473-82. PMID:11937052

Page seeded by OCA on Thu Mar 20 11:28:01 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:1gue.gif|left|200px]]<br /><applet load="1gue" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1gue.gif|left|200px]]
-caption="1gue, resolution 2.27&Aring;" />
-'''SENSORY RHODOPSIN II'''<br />
+ {{Structure
+|PDB= 1gue |SIZE=350|CAPTION= <scene name='initialview01'>1gue</scene>, resolution 2.27&Aring;
+|SITE= <scene name='pdbsite=RET:Cl+Binding+Site+For+Chain+A'>RET</scene>
+|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=RET:RETINAL'>RET</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''SENSORY RHODOPSIN II'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-GUE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Natronomonas_pharaonis Natronomonas pharaonis] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=RET:'>RET</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=RET:Cl+Binding+Site+For+Chain+A'>RET</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUE OCA].
+GUE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Natronomonas_pharaonis Natronomonas pharaonis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUE OCA].
 ==Reference==
-Early structural rearrangements in the photocycle of an integral membrane sensory receptor., Edman K, Royant A, Nollert P, Maxwell CA, Pebay-Peyroula E, Navarro J, Neutze R, Landau EM, Structure. 2002 Apr;10(4):473-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11937052 11937052]
+Early structural rearrangements in the photocycle of an integral membrane sensory receptor., Edman K, Royant A, Nollert P, Maxwell CA, Pebay-Peyroula E, Navarro J, Neutze R, Landau EM, Structure. 2002 Apr;10(4):473-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11937052 11937052]
 [[Category: Natronomonas pharaonis]]
 [[Category: Single protein]]
@@ Line 27: / Line 36: @@
 [[Category: phototaxis]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:54:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:28:01 2008''