2gcs: Difference between revisions

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-[[Image:2gcs.png|left|200px]]
+==Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme==
+<StructureSection load='2gcs' size='340' side='right' caption='[[2gcs]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2gcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GCS FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
+<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AD:2-AMINO-2-DEOXYADENOSINE'>2AD</scene>, <scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gcv|2gcv]], [[2h0s|2h0s]], [[2h0w|2h0w]], [[2h0x|2h0x]], [[2h0z|2h0z]]</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gcs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gcs RCSB], [http://www.ebi.ac.uk/pdbsum/2gcs PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.
-{{STRUCTURE_2gcs|  PDB=2gcs  |  SCENE=  }}
+Structural basis of glmS ribozyme activation by glucosamine-6-phosphate.,Klein DJ, Ferre-D'Amare AR Science. 2006 Sep 22;313(5794):1752-6. PMID:16990543<ref>PMID:16990543</ref>
-===Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_16990543}}
-==About this Structure==
-[[2gcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCS OCA].
 ==See Also==
 *[[Ribozyme|Ribozyme]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:016990543</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Amare, A R.Ferre-D.]]
 [[Category: Klein, D J.]]