1fl2: Difference between revisions

← Older edit Newer edit →

Revision as of 12:10, 20 March 2008

File:1fl2.jpg

, resolution 1.90Å

Ligands:

and

Coordinates:

save as pdb, mmCIF, xml

CATALYTIC CORE COMPONENT OF THE ALKYLHYDROPEROXIDE REDUCTASE AHPF FROM E.COLI

OverviewOverview

Alkylhydroperoxide reductases (AhpR, EC 1.6.4.*) are essential for the oxygen tolerance of aerobic organisms by converting otherwise toxic hydroperoxides of lipids or nucleic acids to the corresponding alcohols. The AhpF component belongs to the family of pyridine nucleotide-disulphide oxidoreductases and channels electrons from NAD(P)H towards the AhpC component which finally reduces cognate substrates. The structure of the catalytic core of the Escherichia coli AhpF (A212-A521) with a bound FAD cofactor was determined at 1.9 A resolution in its oxidized state. The dimeric arrangement of the AhpF catalytic core and the predicted interaction mode between the N-terminal PDO-like domain and the NADPH domain favours an intramolecular electron transfer between the two redox-active disulphide centres of AhpF.

About this StructureAbout this Structure

1FL2 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the catalytic core component of the alkylhydroperoxide reductase AhpF from Escherichia coli., Bieger B, Essen LO, J Mol Biol. 2001 Mar 16;307(1):1-8. PMID:11243797

Page seeded by OCA on Thu Mar 20 11:10:32 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1fl2.jpg|left|200px]]<br /><applet load="1fl2" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1fl2.jpg|left|200px]]
-caption="1fl2, resolution 1.90&Aring;" />
-'''CATALYTIC CORE COMPONENT OF THE ALKYLHYDROPEROXIDE REDUCTASE AHPF FROM E.COLI'''<br />
+ {{Structure
+|PDB= 1fl2 |SIZE=350|CAPTION= <scene name='initialview01'>1fl2</scene>, resolution 1.90&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=FAD:FLAVIN-ADENINE DINUCLEOTIDE'>FAD</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''CATALYTIC CORE COMPONENT OF THE ALKYLHYDROPEROXIDE REDUCTASE AHPF FROM E.COLI'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-FL2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=FAD:'>FAD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FL2 OCA].
+FL2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FL2 OCA].
 ==Reference==
-Crystal structure of the catalytic core component of the alkylhydroperoxide reductase AhpF from Escherichia coli., Bieger B, Essen LO, J Mol Biol. 2001 Mar 16;307(1):1-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11243797 11243797]
+Crystal structure of the catalytic core component of the alkylhydroperoxide reductase AhpF from Escherichia coli., Bieger B, Essen LO, J Mol Biol. 2001 Mar 16;307(1):1-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11243797 11243797]
 [[Category: Escherichia coli]]
 [[Category: Single protein]]
@@ Line 22: / Line 31: @@
 [[Category: reactive oxygen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:39:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:10:32 2008''