1fim: Difference between revisions

Revision as of 12:09, 20 March 2008

, resolution 2.2Å

Coordinates:

MACROPHAGE MIGRATION INHIBITORY FACTOR

OverviewOverview

The tertiary structure of the macrophage migration inhibitory factor (MIF) from rat liver (12,300 Mr) is presented at 2.2 A resolution. Each monomer consists of two beta/alpha/beta motifs aligned in quasi two-fold symmetry, comprising a domain consisting of a four-stranded mixed beta-sheet and two antiparallel alpha-helices. The protein exists as a trimer in the crystal. An extra beta-strand that is almost perpendicular to the other beta-strands joins to the beta-sheet of the neighbouring monomer in the trimer. Unexpected similarities were detected between MIF and two kinds of isomerase.

About this StructureAbout this Structure

1FIM is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the macrophage migration inhibitory factor from rat liver., Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Nishihira J, Sakai M, Nat Struct Biol. 1996 Mar;3(3):259-66. PMID:8605628

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1fim.gif|left|200px]]<br /><applet load="1fim" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1fim.gif|left|200px]]
-caption="1fim, resolution 2.2&Aring;" />
-'''MACROPHAGE MIGRATION INHIBITORY FACTOR'''<br />
+ {{Structure
+|PDB= 1fim |SIZE=350|CAPTION= <scene name='initialview01'>1fim</scene>, resolution 2.2&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE=
+}}
+'''MACROPHAGE MIGRATION INHIBITORY FACTOR'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-FIM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIM OCA].
+FIM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIM OCA].
 ==Reference==
-Crystal structure of the macrophage migration inhibitory factor from rat liver., Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Nishihira J, Sakai M, Nat Struct Biol. 1996 Mar;3(3):259-66. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8605628 8605628]
+Crystal structure of the macrophage migration inhibitory factor from rat liver., Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Nishihira J, Sakai M, Nat Struct Biol. 1996 Mar;3(3):259-66. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8605628 8605628]
 [[Category: Rattus norvegicus]]
 [[Category: Single protein]]
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 [[Category: macrophage]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:39:04 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:09:34 2008''