1jb3: Difference between revisions

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-[[Image:1jb3.png|left|200px]]
+==The Laminin-Binding Domain of Agrin is structurally related to N-TIMP-1==
+<StructureSection load='1jb3' size='340' side='right' caption='[[1jb3]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1jb3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JB3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JB3 FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jb3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jb3 RCSB], [http://www.ebi.ac.uk/pdbsum/1jb3 PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Agrin is the key organizer of postsynaptic differentiation at the neuromuscular junction. This organization activity requires the binding of agrin to the synaptic basal lamina. Binding is conferred by the N-terminal agrin (NtA) domain, which mediates a high-affinity interaction with the coiled coil domain of laminins. Here, we report the crystal structure of chicken NtA at 1.6 A resolution. The structure reveals that NtA harbors an oligosaccharide/oligonucleotide-binding fold with several possible sites for the interaction with different ligands. A high structural similarity of NtA with the protease inhibition domain in tissue inhibitor of metalloproteinases-1 (TIMP-1) supports the idea of additional functions of agrin besides synaptogenic activity.
-{{STRUCTURE_1jb3|  PDB=1jb3  |  SCENE=  }}
+The laminin-binding domain of agrin is structurally related to N-TIMP-1.,Stetefeld J, Jenny M, Schulthess T, Landwehr R, Schumacher B, Frank S, Ruegg MA, Engel J, Kammerer RA Nat Struct Biol. 2001 Aug;8(8):705-9. PMID:11473262<ref>PMID:11473262</ref>
-===The Laminin-Binding Domain of Agrin is structurally related to N-TIMP-1===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_11473262}}
-==About this Structure==
-[[1jb3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JB3 OCA].
 ==See Also==
 *[[Agrin|Agrin]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:011473262</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Gallus gallus]]
 [[Category: Stetefeld, J.]]