1efd: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1efd.gif|left|200px]] | [[Image:1efd.gif|left|200px]] | ||
'''PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME''' | {{Structure | ||
|PDB= 1efd |SIZE=350|CAPTION= <scene name='initialview01'>1efd</scene>, resolution 1.9Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=GCR:GALLICHROME'>GCR</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
1EFD is a [ | 1EFD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EFD OCA]. | ||
==Reference== | ==Reference== | ||
The structure of the ferric siderophore binding protein FhuD complexed with gallichrome., Clarke TE, Ku SY, Dougan DR, Vogel HJ, Tari LW, Nat Struct Biol. 2000 Apr;7(4):287-91. PMID:[http:// | The structure of the ferric siderophore binding protein FhuD complexed with gallichrome., Clarke TE, Ku SY, Dougan DR, Vogel HJ, Tari LW, Nat Struct Biol. 2000 Apr;7(4):287-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10742172 10742172] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 24: | Line 33: | ||
[[Category: periplasmic binding protein-siderophore complex]] | [[Category: periplasmic binding protein-siderophore complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:54:49 2008'' | ||
Revision as of 11:54, 20 March 2008
| |||||||
| , resolution 1.9Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME
OverviewOverview
Siderophore binding proteins play a key role in the uptake of iron in many gram-positive and gram-negative bacteria. FhuD is a soluble periplasmic binding protein that transports ferrichrome and other hydroxamate siderophores. The crystal structure of FhuD from Escherichia coli in complex with the ferrichrome homolog gallichrome has been determined at 1.9 inverted question mark resolution, the first structure of a periplasmic binding protein involved in the uptake of siderophores. Gallichrome is held in a shallow pocket lined with aromatic groups; Arg and Tyr side chains interact directly with the hydroxamate moieties of the siderophore. FhuD possesses a novel fold, suggesting that its mechanisms of ligand binding and release are different from other structurally characterized periplasmic ligand binding proteins.
About this StructureAbout this Structure
1EFD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
ReferenceReference
The structure of the ferric siderophore binding protein FhuD complexed with gallichrome., Clarke TE, Ku SY, Dougan DR, Vogel HJ, Tari LW, Nat Struct Biol. 2000 Apr;7(4):287-91. PMID:10742172
Page seeded by OCA on Thu Mar 20 10:54:49 2008