1ed1: Difference between revisions

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Revision as of 11:53, 20 March 2008

File:1ed1.gif

, resolution 2.1Å

Ligands:

Gene:

GAG (Simian immunodeficiency virus - mac)

Coordinates:

save as pdb, mmCIF, xml

CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.

OverviewOverview

Simian immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of Pr55Gag, the sole protein required for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and assembly of the Pr55Gag shell. Cleavage of Pr55 by the viral protease produces the mature protein of relative molecular mass 17-18K, which underlies the host-derived membrane and is important in both virus entry and nuclear localization of the virion core. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro, the observed virion architecture, and various biological properties of MA.

About this StructureAbout this Structure

1ED1 is a Single protein structure of sequence from Simian immunodeficiency virus - mac. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of SIV matrix antigen and implications for virus assembly., Rao Z, Belyaev AS, Fry E, Roy P, Jones IM, Stuart DI, Nature. 1995 Dec 14;378(6558):743-7. PMID:7501025

Page seeded by OCA on Thu Mar 20 10:53:52 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:1ed1.gif|left|200px]]<br /><applet load="1ed1" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ed1.gif|left|200px]]
-caption="1ed1, resolution 2.1&Aring;" />
-'''CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.'''<br />
+ {{Structure
+|PDB= 1ed1 |SIZE=350|CAPTION= <scene name='initialview01'>1ed1</scene>, resolution 2.1&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=IPA:ISOPROPYL ALCOHOL'>IPA</scene>
+|ACTIVITY=
+|GENE= GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Simian immunodeficiency virus - mac])
+}}
+'''CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-ED1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus_-_mac Simian immunodeficiency virus - mac] with <scene name='pdbligand=IPA:'>IPA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ED1 OCA].
+ED1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus_-_mac Simian immunodeficiency virus - mac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ED1 OCA].
 ==Reference==
-Crystal structure of SIV matrix antigen and implications for virus assembly., Rao Z, Belyaev AS, Fry E, Roy P, Jones IM, Stuart DI, Nature. 1995 Dec 14;378(6558):743-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7501025 7501025]
+Crystal structure of SIV matrix antigen and implications for virus assembly., Rao Z, Belyaev AS, Fry E, Roy P, Jones IM, Stuart DI, Nature. 1995 Dec 14;378(6558):743-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7501025 7501025]
 [[Category: Simian immunodeficiency virus - mac]]
 [[Category: Single protein]]
@@ Line 22: / Line 31: @@
 [[Category: trimeric association]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:26:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:53:52 2008''