Protein phosphatase: Difference between revisions

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{{STRUCTURE_3k7v|  PDB=3k7v  | SIZE=400| SCENE= |right|CAPTION=Human PP2A catalytic (pink) and regulatory (grey) subunits complex with tumor-inducing toxin and sulfate [[3k7v]] }}
{{STRUCTURE_3k7v|  PDB=3k7v  | SIZE=400| SCENE= |right|CAPTION=Human PP2A catalytic (pink) and regulatory (grey) subunits complex with tumor-inducing toxin and sulfate [[3k7v]] }}


'''Protein phosphatases''' (PP) regular protein phosphorylation and thus are key in intracellular signal transduction processes.   PP1 is a serine/threonine phosphatase.  PP2A targets proteins in the oncogenic signaling pathways.  PP2C are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways.  PP4 regulates a variety of cellular functions.  PP5 is activated by lipids and is involved in signal transduction.  For PP2A see also [[HEAT Repeat]].
'''Protein phosphatases''' (PP) regular protein phosphorylation and thus are key in intracellular signal transduction processes.<br />
*  '''PP1''' is a serine/threonine phosphatase.<br />
* '''PP2A''' targets proteins in the oncogenic signaling pathways. For PP2A see also [[HEAT Repeat]].<br />
* '''PP2C''' are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways.<br />
* '''PP4''' regulates a variety of cellular functions.<br />
* '''PP5''' is activated by lipids and is involved in signal transduction.   


== 3D Structures of protein phosphatase==
== 3D Structures of protein phosphatase==

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Alexsandra Tifane Santos do Nascimento