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[[ | ==CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG== | ||
<StructureSection load='1dc0' size='340' side='right' caption='[[1dc0]], [[Resolution|resolution]] 1.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1dc0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DC0 FirstGlance]. <br> | |||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dc0 RCSB], [http://www.ebi.ac.uk/pdbsum/1dc0 PDBsum]</span></td></tr> | |||
<table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition. | |||
The structure of a stable intermediate in the A <--> B DNA helix transition.,Ng HL, Kopka ML, Dickerson RE Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:10688897<ref>PMID:10688897</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Dickerson, R E.]] | [[Category: Dickerson, R E.]] | ||
[[Category: Kopka, M L.]] | [[Category: Kopka, M L.]] | ||
Revision as of 09:31, 4 September 2014
CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATGCRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG
Structural highlights
Publication Abstract from PubMedThe DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition. The structure of a stable intermediate in the A <--> B DNA helix transition.,Ng HL, Kopka ML, Dickerson RE Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:10688897[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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