4c28: Difference between revisions

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-'''Unreleased structure'''
+==Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(4-chlorophenyl)piperazin-1-yl)-2-fluorobenzamide.==
+<StructureSection load='4c28' size='340' side='right' caption='[[4c28]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
-The entry 4c28 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4c28]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C28 FirstGlance]. <br>
-Authors: Vieira, D.F., Calvet, C.M., Choi, J.Y., Cameron, M.D., Gut, J., Kellar, D., Siqueira-Neto, J.L., McKerrow, J.H., Roush, W.R., Podust, L.M.
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TW5:(R)-N-(3-(1H-INDOL-3-YL)-1-OXO-1-(PYRIDIN-4-YLAMINO)PROPAN-2-YL)-4-(4-(4-CHLOROPHENYL)PIPERAZIN-1-YL)-2-FLUOROBENZAMIDE'>TW5</scene><br>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c27|4c27]]</td></tr>
-Description: Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor ( R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-( 4-chlorophenyl)piperazin-1-yl)-2-fluorobenzamide.
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c28 RCSB], [http://www.ebi.ac.uk/pdbsum/4c28 PDBsum]</span></td></tr>
+<table>
+__TOC__
+</StructureSection>
+[[Category: Sterol 14-demethylase]]
+[[Category: Calvet, C M.]]
+[[Category: Cameron, M D.]]
+[[Category: Choi, J Y.]]
+[[Category: Gut, J.]]
+[[Category: Kellar, D.]]
+[[Category: McKerrow, J H.]]
+[[Category: Podust, L M.]]
+[[Category: Roush, W R.]]
+[[Category: Siqueira-Neto, J L.]]
+[[Category: Vieira, D F.]]
+[[Category: Chagas disease]]
+[[Category: Oxidoreductase]]
+[[Category: Sterol biosynthesis]]