Mitogen-activated protein kinase: Difference between revisions

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{{STRUCTURE_1erk| right| PDB=1erk  |  SCENE=Mitogen-activated_protein_kinase/Cv/1 |CAPTION=Mitogen-activated protein kinase, [[1erk]] }}
{{STRUCTURE_1erk| right| PDB=1erk  |  SCENE=Mitogen-activated_protein_kinase/Cv/1 |CAPTION=Mitogen-activated protein kinase, [[1erk]] }}


[[Mitogen-activated protein kinase]] (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more.  MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation.  MAPK1 and MAPK3 are activated in response to growth factors. For MAPK2 representations see [[Michael Roberts/BIOL115/ERK2]].  MAPK6 is activated by phorbol esters. MAPK7 is activated by stress stimuli.  MAPK8, MAPK9, MAPK10 (called also c-Jun N-terminal kinase 3 or JNK3), MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. MAPK11 (also called p38-β MAPK),  MAPK12 (also called p38-γ MAPK),  MAPK13 (also called p38-δ MAPK),  MAPK14(also called p38-α MAPK) belong to the class called p38 MAPK.  images on the left and right  correspond to one representative MAPK structure, ''i.e.'' the rat MAPK1 ([[1erk]]).
[[Mitogen-activated protein kinase]] (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more.  MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation.  <br />
* '''MAPK1''' and '''MAPK3''' are activated in response to growth factors.<br />
* For '''MAPK2''' representations see [[Michael Roberts/BIOL115/ERK2]].<br />
* '''MAPK6''' is activated by phorbol esters.<br />
* '''MAPK7''' is activated by stress stimuli.<br />
* '''MAPK8, MAPK9, MAPK10''' (called also c-Jun N-terminal kinase 3 or JNK3), '''MAPK11, MAPK12, MAPK13, MAPK14''' are stress-activated.<br />
* '''MAPK11''' (also called p38-β MAPK),  '''MAPK12''' (also called p38-γ MAPK),  '''MAPK13''' (also called p38-δ MAPK),  '''MAPK14''' (also called p38-α MAPK) belong to the class called p38 MAPK.   


== 3D Structures of Mitogen-activated protein kinase ==
== 3D Structures of Mitogen-activated protein kinase ==

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Alexander Berchansky, Michal Harel, Joel L. Sussman
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