Interferon regulatory factor: Difference between revisions
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<StructureSection load='1if1' size='400' side='right' caption='Structure of mouse interferon regulatory factor DNA-binding domain dimer complex with DNA (PDB entry [[1if1]])' scene=''> | <StructureSection load='1if1' size='400' side='right' caption='Structure of mouse interferon regulatory factor DNA-binding domain dimer complex with DNA (PDB entry [[1if1]])' scene=''> | ||
'''Interferon regulatory factor''' (IRF) regulate transcription of interferons. IRF-1 functions as a transcriptional activator by binding to an interferon-stimulated response element in the gene promoter. IRF-3 and IRF-7 are activated by viruses or after binding to Toll-like receptors. IRF-4 is lymphoid-specific and functions in the development of immune cells. | '''Interferon regulatory factor''' (IRF) regulate transcription of interferons.<br /> | ||
* '''IRF-1''' functions as a transcriptional activator by binding to an interferon-stimulated response element in the gene promoter.<br /> | |||
* '''IRF-3''' and '''IRF-7''' are activated by viruses or after binding to Toll-like receptors.<br /> | |||
* '''IRF-4''' is lymphoid-specific and functions in the development of immune cells. | |||
==3D structures of interferon regulatory factor== | ==3D structures of interferon regulatory factor== | ||