Growth factor receptor-bound protein: Difference between revisions
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<StructureSection load='1tze' size='350' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry [[1tze]])' scene=''> | <StructureSection load='1tze' size='350' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry [[1tze]])' scene=''> | ||
'''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway. '''GRB10''' interacts with insulin receptor and insulin-like growth factor receptors | '''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> | ||
* '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction.<br /> | |||
* '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway.<br /> | |||
* '''GRB10''' interacts with insulin receptor and insulin-like growth factor receptors. For additional details on GRB10 see [[Grb10 SH2 Domain]].<br /> | |||
==3D structures of Grb== | ==3D structures of Grb== | ||
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[[2auh]] – hGRB14 BPS domain + insulin receptor kinase domain<br /> | [[2auh]] – hGRB14 BPS domain + insulin receptor kinase domain<br /> | ||
[[4k81]] – hGRB14 RA and PH domains + GTPase Hras<br /> | [[4k81]] – hGRB14 RA and PH domains + GTPase Hras<br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 12:47, 27 August 2014
<StructureSection load='1tze' size='350' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry 1tze)' scene=>
Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains.
- GRB2 links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction.
- GRB7 interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway.
- GRB10 interacts with insulin receptor and insulin-like growth factor receptors. For additional details on GRB10 see Grb10 SH2 Domain.
3D structures of Grb3D structures of Grb
Updated on 27-August-2014
GRB2GRB2
GRB2 C terminal SH3 domain
1gfc, 1gfd – hGRB2 C terminal SH3 domain - NMR
2vvk, 2vwf, 2w0z – hGRB2 C terminal SH3 domain
1io6 – hGRB2 C terminal SH3 domain + ligand peptide - NMR
1gcq – hGRB2 C terminal SH3 domain + VAV proto-oncogene SH3 domain
GRB2 N terminal SH3 domain
1gbr, 1gbq, 2gbq, 3gbq, 4gbq – mGRB2 N terminal SH3 domain + Sos-A peptide – mouse - NMR
1aze – mGRB2 N terminal SH3 domain + Sos-A peptide - NMR
GRB2 SH2 domain
1jyu – hGRB2 SH2 domain
1ghu – hGRB2 SH2 domain (mutant) - NMR
1fhs – hGRB2 SH2 domain - NMR
1x0n – hGRB2 SH2 domain + inhibitor - NMR
2huw – hGRB2 SH2 domain + cyclopropane derivative
1cj1 – hGRB2 SH2 domain + phosphor-Tyr derivative
2aoa, 2aob – hGRB2 SH2 domain + peptide mimetic
1tze, 1bmb, 1bm2, 1zfp, 1fyr, 1jyq, 1jyr, 2h5k, 3c7i, 3imd, 3imj, 3in7, 3in8, 3kfj, 3n8m, 3n7y, 3n84, 3mxc, 3mxy, 3ov1, 3ove, 3s8l, 3s8n, 3s8o, 1zfp – hGRB2 SH2 domain + phosphor-Tyr peptide
1qg1 – hGRB2 SH2 domain + phosphor-Tyr peptide - NMR
3wa4 - hGRB2 SH2 domain + CD28 peptide
GRB4GRB4
4e6r – hGRB4 C terminal SH3 domain
GRB7GRB7
2qms – hGRB7 SH2 domain
1mw4, 2l4k – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR
3pqz – hGRB7 SH2 domain + cyclic peptide
1wgr – hGRB7 RA domain - NMR
GRB10GRB10
1nrv – hGRB10 SH2 domain
3m7f – hGRB10 SH2 domain + NEDD4 C2 domain
3hk0 – hGRB10 RA and PH domains
GRB14GRB14
2aug – hGRB14 SH2 domain
2auh – hGRB14 BPS domain + insulin receptor kinase domain
4k81 – hGRB14 RA and PH domains + GTPase Hras