Fibroblast growth factor: Difference between revisions
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'''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family. FGF signaling is important in the pathogenesis of a variety of tumor types. FGF1 is called acidic FGF | '''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family. FGF signaling is important in the pathogenesis of a variety of tumor types.<br /> | ||
* '''FGF1''' is called acidic FGF.<br /> | |||
* '''FGF2''' is called basic FGF.<br /> | |||
* '''FGF7''' is called keratinocyte growth factor which is present in the eiptheliazation-phase of wound healing when keratinocytes are covering the wound. | |||
==3D structures of fibroblast growth factor== | ==3D structures of fibroblast growth factor== |